
Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle | Tedesco FS, Moyle LA and Perdiguero E. Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle. Methods in Molecular Biology; 2017; 1556: 129-147 |
Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro | Progress toward finding a cure for muscle diseases has been slow because of the absence of relevant cellular models and the lack of a reliable source of muscle progenitors for biomedical investigation. |
Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy | Using embryonic development as a guide, PluriMes researchers and their collaborators established conditions for the differentiation of pluripotent stem cells into musculoskeletal progenitors without the introduction of transgenes or cell sorting. |
No Identical “Mesenchymal Stem Cells” at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels | This study has important applicative implications. It demonstrates that, in contrast with the hypothesis of the existence of ubiquitous and equivalent mesodermal progenitors (“Mesenchymal Stem Cells”), human post-natal mesodermal tissues include distinct classes of progenitors able to regenerate only the tissue in which they reside. |
Cell‐Instructive Microgels with Tailor‐Made Physicochemical Properties | A microfluidic in vitro cell encapsulation platform to systematically test the effects of microenvironmental parameters on cell fate in 3D is developed in this paper. |
Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues | Gobaa S, Hoehnel S and Lutolf MP. Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues. Integrative Biology, 7 (10), 1135-42, 2015 Oct. Epub 2015 Mar 9. |
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells | PluriMes researchers and their collaborators developed defined conditions for the differentiation and expansion of LPM derivative progenitors that can be differentiated into cardiac muscle, pacemaker-like cells and endothelial cells. |
Efficient Derivation and Inducible Differentiation of Expandable Skeletal Myogenic Cells from Human ES and Patient-Specific iPS Cells | PluriMes researchers have published a detailed protocol in which human pluripotent stem cells are first differentiated into expandable cells resembling human mesoangioblasts and subsequently efficiently induced to muscle cells. |
Osteoblast-specific expression of the Fibrous Dysplasia (FD) causing mutation, GsαR201C produces a high bone mass phenotype but does not reproduce FD in the mouse | The study reports on a novel transgenic mouse models that may be important to understand the role of the Gsa gene in bone forming cells. |
Culture Adaptation Alters Transcriptional Hierarchies Among Single Human Embryonic Stem Cells Reflecting Altered Patterns of Differentiation | This single cell gene expression analysis demonstrates the heterogeneity of undifferentiated human pluripotent stem cells, and that they can be classified into distinct subgroups. |